Nucleic acid drugs are mainly divided into two major categories: small nucleic acid drugs and mRNA. Small nucleic acid drugs, also known as oligonucleotide drugs,…
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Author: Krystalbeily
Strain Improvement in Yeast
Yeast is a single-celled and versatile microorganism that is widely used in various industries, such as brewing, food, and biotechnology. However, not all yeast strains…
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The Background of Circular RNA Synthesis
In recent years, nucleic acid therapy involving various types of ribonucleic acids (RNAs), including messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA), has…
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PEG cGMP Manufacture: From Material Preparation to Quality Control
PEG manufacturing (Polyethylene Glycol) involves several steps and processes. Here is a general outline of how to conduct PEG manufacturing in a cGMP (current Good Manufacturing…
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Bioconjugation Strategies for Enhancing Drug Delivery and Therapeutic Efficacy
In recent years, bioconjugation has emerged as a powerful strategy for improving drug delivery and enhancing therapeutic efficacy. By linking drugs to various biological entities,…
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ADC Cleavable Linker: Classification and Mechanism of Action
Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them. ADC is a monoclonal antibody covalently…
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Fermentation Production of ADC Payloads
Targeted therapies have significantly advanced the field of cancer therapy, and among these, antibody-drug conjugates (ADCs) have emerged as a viable therapeutic strategy. ADCs increase…
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PEG Chemical Structure
This article will introduce PEG chemical structure, PEG synthesis, and PEG properties. Polyethylene glycol (PEG), a compound composed of repeated ethylene glycol units [-(CH2CH2O)n], is also known…
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Drug-to-Antibody Ratio Analysis Methods
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody drug conjugates (ADCs). Over the years, several ADC bioanalytical methods have been developed to better…
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