The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to…
View More Antibody-Drug Conjugates: New Strategies of ADC PayloadsAuthor: Krystalbeily
Exploration of Terpenoid Biosynthesis in Filamentous Fungi
Using synthetic biology methods allows for the more efficient production of highly complex drug molecules compared to traditional chemical methods, with increased stability and controllability.…
View More Exploration of Terpenoid Biosynthesis in Filamentous FungiMicrobial Production of Bio-based Plastics
At the 5th United Nations Environment Assembly (UNEA-5) held in March 2022, 175 countries signed a resolution to end plastic pollution. The aim is to achieve…
View More Microbial Production of Bio-based PlasticsCMC Regulatory Considerations for ADCs
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a…
View More CMC Regulatory Considerations for ADCsHybridization-ELISA in the Bioassay of Oligonucleotide Drugs
Introduction of Oligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense…
View More Hybridization-ELISA in the Bioassay of Oligonucleotide DrugsDiscovery of Molecular Glue Degraders
Background The use of small molecules to selectively regulate the function of proteins is the cornerstone of the development of medicine. However, only about 20%…
View More Discovery of Molecular Glue DegradersBiotin PEG
What are Biotinylation and Biotinylated PEG? Biotinylation is the process of covalently attaching biotin to molecules (such as amino acids, peptides, antibodies, or proteins). Due…
View More Biotin PEGDevelopment of mRNA-Directed Delivery – LNP Delivery System
During the COVID-19 pandemic, the success of mRNA vaccines has greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as…
View More Development of mRNA-Directed Delivery – LNP Delivery SystemBispecific Antibodies and Bispecific Antibody ADCs
With the rapid development of antibody-drug conjugate (ADC), more and more companies have entered the field of ADC research and development, and various types of ADC…
View More Bispecific Antibodies and Bispecific Antibody ADCsMechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides
What are Antimicrobial Peptides? Antimicrobial peptides (AMPs) are naturally occurring peptide molecules found in various organisms, including humans, animals, plants, and microorganisms. These peptides play a crucial…
View More Mechanisms to Combat Drug Resistance: Overview of Antimicrobial Peptides